Non-clear cell renal cell carcinomas most frequently harbor alterations in TP53, NF2, SETD2, CDKN2A, and CDKN2B [2].

Most Commonly Altered Genes in Non-Clear Cell Renal Cell Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, CDKN2B Loss, and SETD2 Mutation are the most common alterations in non-clear cell renal cell carcinoma [2].

Top Alterations in Non-Clear Cell Renal Cell Carcinoma

Significant Genes in Non-Clear Cell Renal Cell Carcinoma



TFE3 +

TSC1 +

Disease Details

Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Chromophobe Renal Cell Carcinoma, Collecting Duct Carcinoma, Translocation-Associated Renal Cell Carcinoma, Unclassified Renal Cell Carcinoma, and Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
OncoTree Name
Renal Non-Clear Cell Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.