Non-clear cell renal cell carcinomas most frequently harbor alterations in TP53, NF2, SETD2, CDKN2A, and CDKN2B [2].

Most Commonly Altered Genes in Non-Clear Cell Renal Cell Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, CDKN2B Loss, and SETD2 Mutation are the most common alterations in non-clear cell renal cell carcinoma [2].

Top Alterations in Non-Clear Cell Renal Cell Carcinoma

Significant Genes in Non-Clear Cell Renal Cell Carcinoma



TFE3 +

TSC1 +

Disease Details

Renal Cell Carcinoma
Translocation-Associated Renal Cell Carcinoma, Chromophobe Renal Cell Carcinoma, Mucinous Tubular and Spindle Cell Carcinoma of the Kidney, Sarcomatoid Renal Cell Carcinoma, Collecting Duct Carcinoma, Papillary Renal Cell Carcinoma, and Unclassified Renal Cell Carcinoma
OncoTree Name
Renal Non-Clear Cell Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.