Non-Secretory Plasma Cell Myeloma
NCI Definition: A rare type of multiple myeloma in which the plasma cells synthesize but do not secrete immunoglobulins. As a result, none of the immunoglobulins appear out of the normal range. The symptoms are generally the same with those of immunoglobulin-secreting myeloma; however, the incidence of renal insufficiency is lower in non-secretory myeloma. The diagnosis can be missed because of the absence of monoclonal immunoglobulin in the serum or urine. 
There is 1 clinical trial for non-secretory plasma cell myeloma, of which 1 is open and 0 are completed or closed. Of the trial that contains non-secretory plasma cell myeloma as an inclusion criterion, 1 is phase 1 (1 open).
Cereblon e3 ubiquitin ligase modulating agent cc-92480 and dexamethasone are the most common interventions in non-secretory plasma cell myeloma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.