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Associated Genetic Biomarkers
NCI Definition: A melanoma that arises from the structures of the eye or ocular adnexa. 
Ocular melanomas most frequently harbor alterations in GNA11, GNAQ, BAP1, SF3B1, and MYC .
GNA11 Mutation, GNA11 Exon 5 Mutation, GNA11 Codon 209 Missense, GNA11 Q209L, and GNAQ Mutation are the most common alterations in ocular melanoma .
There are 6 clinical trials for ocular melanoma, of which 5 are open and 1 is completed or closed. Of the trials that contain ocular melanoma as an inclusion criterion, 2 are phase 1 (2 open) and 4 are phase 2 (3 open).
Monosomy is the most frequent gene inclusion criterion for ocular melanoma clinical trials .
Nivolumab, cisplatin, and ipilimumab are the most common interventions in ocular melanoma clinical trials.
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.