Associated Genetic Biomarkers


NCI Definition: A melanoma that arises from the structures of the eye or ocular adnexa. [1]

Ocular melanomas most frequently harbor alterations in GNA11, GNAQ, BAP1, SF3B1, and MYC [2].

Most Commonly Altered Genes in Ocular Melanoma

GNA11 Mutation, GNA11 Exon 5 Mutation, GNA11 Codon 209 Missense, GNA11 Q209L, and GNAQ Mutation are the most common alterations in ocular melanoma [2].

Top Alterations in Ocular Melanoma

Disease Details

Eye Melanoma, Melanoma of the Eye, Melanoma of Eye
Retinal Melanoma, Conjunctival Melanoma, Corneal Melanoma, Uveal Melanoma, and Eyelid Melanoma
OncoTree Name
Ocular Melanoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.