Overview

NCI Definition: A WHO grade II tumor composed of a conspicuous mixture of two distinct neoplastic cell types morphologically resembling the tumor cells in oligodendroglioma and diffuse astrocytoma. (WHO) [1]

Oligoastrocytomas most frequently harbor alterations in IDH1, TP53, and ATRX [2].

Most Commonly Altered Genes in Oligoastrocytoma

IDH1 Mutation, IDH1 Codon 132 Missense, IDH1 R132H, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in oligoastrocytoma [2].

Top Alterations in Oligoastrocytoma

Significant Genes in Oligoastrocytoma

IDH1 +

IDH2 +

Disease Details

Synonyms
WHO Grade II Mixed Glioma, Mixed Astrocytic-Oligodendroglial Neoplasm, Mixed Astrocytic-Oligodendroglial Tumor, Mixed Oligo-Astrocytoma, MIXED GLIOMA, BENIGN, Mixed Astrocytoma-Oligodendroglioma
Parent(s)
Mixed Glioma
OncoTree Name
Oligoastrocytoma
OncoTree Code
OAST

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.