Associated Genetic Biomarkers
NCI Definition: A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). (Adapted from WHO) 
Oligodendrogliomas most frequently harbor alterations in IDH1, CIC, NOTCH1, PIK3CA, and IDH2 .
IDH1 Mutation, IDH1 Codon 132 Missense, IDH1 R132H, NOTCH1 Mutation, and PIK3CA Mutation are the most common alterations in oligodendroglioma .
There are 9 clinical trials for oligodendroglioma, of which 9 are open and 0 are completed or closed. Of the trials that contain oligodendroglioma as an inclusion criterion, 1 is early phase 1 (1 open), 2 are phase 1 (2 open), 1 is phase 1/phase 2 (1 open), 4 are phase 2 (4 open), and 1 is phase 3 (1 open).
IDH1, IDH2, and HLA-A*02 are the most frequent gene inclusion criteria for oligodendroglioma clinical trials .
Abemaciclib, temozolomide, and vorasidenib are the most common interventions in oligodendroglioma clinical trials.
Significant Genes in Oligodendroglioma
IDH1 is altered in 81.17% of oligodendroglioma patients .
IDH1 is an inclusion eligibility criterion in 3 clinical trials for oligodendroglioma, of which 3 are open and 0 are closed. Of the trials that contain IDH1 status and oligodendroglioma as inclusion criteria, 1 is phase 1 (1 open), 1 is phase 2 (1 open), and 1 is phase 3 (1 open) .
IDH2 is altered in 13.33% of oligodendroglioma patients .
IDH2 is an inclusion eligibility criterion in 2 clinical trials for oligodendroglioma, of which 2 are open and 0 are closed. Of the trials that contain IDH2 status and oligodendroglioma as inclusion criteria, 1 is phase 2 (1 open) and 1 is phase 3 (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.