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Oligodendroglioma

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Associated Genetic Biomarkers

Overview

NCI Definition: A well-differentiated (WHO grade II), diffusely infiltrating neuroglial tumor, typically located in the cerebral hemispheres. It is composed predominantly of cells which morphologically resemble oligodendroglia. The neoplastic cells have rounded homogeneous nuclei and, on paraffin sections, a swollen, clear cytoplasm ('honeycomb' appearance). (Adapted from WHO) [1]

Oligodendrogliomas most frequently harbor alterations in IDH1, CIC, NOTCH1, PIK3CA, and IDH2 [2].

Most Commonly Altered Genes in Oligodendroglioma

IDH1 Mutation, IDH1 Codon 132 Missense, IDH1 R132H, NOTCH1 Mutation, and PIK3CA Mutation are the most common alterations in oligodendroglioma [2].

Top Alterations in Oligodendroglioma

Clinical Trials

View Clinical Trials for Oligodendroglioma

Significant Genes in Oligodendroglioma

IDH1 +

IDH2 +

Disease Details

Synonyms
Oligodendroglioma, NOS, WHO Grade II Oligodendroglial Neoplasm, Oligodendroglioma WHO Grade II, Well Differentiated Oligodendroglioma, WHO Grade II Oligodendroglial Tumor, Oligodendroglioma, WHO grade II, Well Differentiated Oligodendroglial Tumor, OLIGODENDROGLIOMA, UNDETERMINED
Parent(s)
WHO Grade II Glioma
Children
Adult Oligodendroglioma, Childhood Oligodendroglioma, and Brain Oligodendroglioma
OncoTree Name
Oligodendroglioma
OncoTree Code
ODG

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.