Overview

NCI Definition: A carcinoma arising in the oral cavity. Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums. Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma. [1]

Oral cavity carcinomas most frequently harbor alterations in TP53, CDKN2A, NOTCH1, PIK3CA, and KMT2D [2].

Most Commonly Altered Genes in Oral Cavity Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, CDKN2A Mutation, and PIK3CA Mutation are the most common alterations in oral cavity carcinoma [2].

Top Alterations in Oral Cavity Carcinoma

Significant Genes in Oral Cavity Carcinoma

CCND1 +

EGFR +

ERBB2 +

Disease Details

Synonyms
Carcinoma of Mouth, Oral Cavity Cancer, Mouth Cancer, Carcinoma of the Oral Cavity, Mouth Carcinoma, oral cavity cancer, Carcinoma of Oral Cavity
Parent(s)
Malignant Oral Cavity Neoplasm
Children
Oral Cavity Squamous Cell Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.