Overview

NCI Definition: An adenocarcinoma that arises from the ovary. It is the most common type of ovarian carcinoma. It includes the serous adenocarcinoma, mucinous adenocarcinoma, clear cell adenocarcinoma, and endometrioid adenocarcinoma. [1]

Ovarian adenocarcinomas most frequently harbor alterations in TP53, KRAS, CCNE1, PIK3CA, and BRCA1 [2].

Most Commonly Altered Genes in Ovarian Adenocarcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, TP53 Frameshift, and TP53 Nonsense are the most common alterations in ovarian adenocarcinoma [2].

Top Alterations in Ovarian Adenocarcinoma

Disease Details

Synonyms
Adenocarcinoma of Ovary, Adenocarcinoma of the Ovary
Parent(s)
Adenocarcinoma
Children
Ovarian Mucinous Adenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian Clear Cell Adenocarcinoma, Ovarian Serous Adenocarcinoma, and Ovarian Cystadenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.