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Ovarian Clear Cell Tumor

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Associated Genetic Biomarkers

Overview

NCI Definition: A benign, borderline, or malignant epithelial tumor of the ovary that is characterized by a predominance of clear and hobnail cells. [1]

Ovarian clear cell tumors most frequently harbor alterations in PIK3CA, ARID1A, TP53, KRAS, and PTEN [2].

Most Commonly Altered Genes in Ovarian Clear Cell Tumor

PIK3CA Mutation, ARID1fs, ARID1A Mutation, ARID1A Nonsense, and PIK3CA Codon 1047 Missense are the most common alterations in ovarian clear cell tumor [2].

Top Alterations in Ovarian Clear Cell Tumor

Clinical Trials

View Clinical Trials for Ovarian Clear Cell Tumor

Significant Genes in Ovarian Clear Cell Tumor

BRCA1 +

BRCA2 +

Disease Details

Parent(s)
Ovarian Epithelial Tumor
Children
Malignant Ovarian Clear Cell Tumor, Ovarian Clear Cell Adenofibroma, Ovarian Clear Cell Cystadenofibroma, and Borderline Ovarian Clear Cell Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.