NCI Definition: A benign, borderline, or malignant epithelial tumor of the ovary that is characterized by a predominance of clear and hobnail cells. [1]

Ovarian clear cell tumors most frequently harbor alterations in ARID1A, PIK3CA, TP53, PPP2R1A, and ARID1B [2].

Most Commonly Altered Genes in Ovarian Clear Cell Tumor

ARID1A Mutation, PIK3CA Mutation, ARID1A Frameshift, ARID1A Nonsense, and TP53 Mutation are the most common alterations in ovarian clear cell tumor [2].

Top Alterations in Ovarian Clear Cell Tumor

Significant Genes in Ovarian Clear Cell Tumor



MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Ovarian Epithelial Tumor
Ovarian Clear Cell Adenofibroma, Borderline Ovarian Clear Cell Tumor, Ovarian Clear Cell Cystadenofibroma, and Malignant Ovarian Clear Cell Tumor


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.