Overview

NCI Definition: An endometrioid adenocarcinoma arising from the ovary. It comprises 10% to 25% of all primary ovarian carcinomas. Grossly, endometrioid carcinoma may present as a cystic or solid mass. Microscopically, the tumor greatly resembles the appearance of the ordinary type of endometrial adenocarcinoma. As a group, endometrioid carcinoma has a prognosis twice as good as that of serous or mucinous carcinoma. [1]

Ovarian endometrioid adenocarcinomas most frequently harbor alterations in ARID1A, PTEN, CTNNB1, PIK3CA, and KRAS [2].

Most Commonly Altered Genes in Ovarian Endometrioid Adenocarcinoma

ARID1A Mutation, CTNNB1 Mutation, PTEN Mutation (somatic), PTEN Mutation (germline), and PTEN Mutation are the most common alterations in ovarian endometrioid adenocarcinoma [2].

Top Alterations in Ovarian Endometrioid Adenocarcinoma

Significant Genes in Ovarian Endometrioid Adenocarcinoma

MLH1 +

MSH2 +

MSH6 +

PMS2 +

Disease Details

Synonyms
Endometrioid Cancer of Ovary, Endometrioid Adenocarcinoma of Ovary, Endometrioid Adenocarcinoma of the Ovary, Endometrioid Cancer of the Ovary, Ovarian Endometrioid Adenocarcinoma NOS, Endometrioid Carcinoma of the Ovary, Ovarian Endometrioid Carcinoma, Ovarian Endometrioid Adenocarcinoma Not Otherwise Specified, Ovarian Endometrioid Cancer, Endometrioid Carcinoma of Ovary
Parent(s)
Ovarian Endometrioid Tumor
OncoTree Name
Endometrioid Ovarian Cancer
OncoTree Code
EOV

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.