Overview

NCI Definition: A benign, borderline, or malignant epithelial tumor of the ovary characterized by the presence of glands and/or cysts lined by neoplastic cells that resemble endometrial cells. [1]

Ovarian endometrioid tumors most frequently harbor alterations in TP53, KRAS, PIK3CA, ARID1A, and PTEN [2].

Most Commonly Altered Genes in Ovarian Endometrioid Tumor

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PIK3CA Mutation, and ARID1A Mutation are the most common alterations in ovarian endometrioid tumor [2].

Top Alterations in Ovarian Endometrioid Tumor

Significant Genes in Ovarian Endometrioid Tumor

BRCA1 +

BRCA2 +

ERBB2 +

MLH1 +

MSH2 +

MSH6 +

PMS2 +

Disease Details

Synonyms
Endometrioid Neoplasm of Ovary, Ovarian Endometrioid Neoplasm, Endometrioid Neoplasm of the Ovary
Parent(s)
Ovarian Epithelial Tumor
Children
Ovarian Carcinosarcoma, Ovarian Endometrioid Adenocarcinofibroma, Borderline Ovarian Endometrioid Tumor, and Ovarian Endometrioid Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.