Overview

NCI Definition: A neoplasm that arises from the ovary and originates from germ cells. Representative examples include teratoma, embryonal carcinoma, yolk sac tumor, and dysgerminoma. [1]

Ovarian germ cell tumors most frequently harbor alterations in TP53, KRAS, KMT2D, PIK3CD, and PIK3CA [2].

Most Commonly Altered Genes in Ovarian Germ Cell Tumor

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 5 Mutation, and KMT2D Mutation are the most common alterations in ovarian germ cell tumor [2].

Top Alterations in Ovarian Germ Cell Tumor

Disease Details

Synonyms
Ovary germ cell tumor, Germ Cell Neoplasm of Ovary, Germ Cell Tumor of Ovary, Germ Cell Tumor of the Ovary, Germ Cell Neoplasm of the Ovary, Ovarian Germ Cell Neoplasm
Parent(s)
Ovarian Neoplasm
Children
Ovarian Teratoma, Childhood Ovarian Germ Cell Tumor, and Malignant Ovarian Germ Cell Tumor
OncoTree Name
Ovarian Germ Cell Tumor
OncoTree Code
OGCT

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.