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Ovarian Mixed Epithelial Tumor

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Associated Genetic Biomarkers

Overview

NCI Definition: A benign, borderline, or malignant mixed epithelial tumor of the ovary. It is characterized by the presence of more than one epithelial cell type, most often serous and endocervical-type mucinous. [1]

Ovarian mixed epithelial tumors most frequently harbor alterations in TP53, KRAS, PIK3CA, NF1, and KMT2D [2].

Most Commonly Altered Genes in Ovarian Mixed Epithelial Tumor

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in ovarian mixed epithelial tumor [2].

Top Alterations in Ovarian Mixed Epithelial Tumor

Clinical Trials

View Clinical Trials for Ovarian Mixed Epithelial Tumor

Significant Genes in Ovarian Mixed Epithelial Tumor

BRCA1 +

BRCA2 +

Disease Details

Synonyms
Ovarian Mixed Epithelial Neoplasm, Mixed Epithelial Neoplasm of the Ovary, Mixed Epithelial Neoplasm of Ovary, Mixed Epithelial Tumor of the Ovary, Mixed Epithelial Tumor of Ovary, Ovarian Seromucinous Tumor
Parent(s)
Ovarian Epithelial Tumor
Children
Malignant Ovarian Mixed Epithelial Tumor and Ovarian Seromucinous Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.