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Ovarian Mucinous Adenocarcinoma

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Associated Genetic Biomarkers

Overview

NCI Definition: An invasive adenocarcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that contain intracytoplasmic mucin. There is cellular atypia, increased layering of cells, complexity of glands, and papillary formations. [1]

Ovarian mucinous adenocarcinomas most frequently harbor alterations in KRAS, TP53, CDKN2A, CDKN2B, and SMAD4 [2].

Most Commonly Altered Genes in Ovarian Mucinous Adenocarcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in ovarian mucinous adenocarcinoma [2].

Top Alterations in Ovarian Mucinous Adenocarcinoma

Clinical Trials

View Clinical Trials for Ovarian Mucinous Adenocarcinoma

Significant Genes in Ovarian Mucinous Adenocarcinoma

BRCA1 +

BRCA2 +

Disease Details

Synonyms
Mucinous Carcinoma of Ovary, Mucinous Carcinoma of the Ovary, Mucinous Adenocarcinoma of Ovary, Mucinous Adenocarcinoma of the Ovary, Ovarian Mucinous Carcinoma
Parent(s)
Ovarian Adenocarcinoma
Children
Ovarian Mucinous Cystadenocarcinoma
OncoTree Name
Mucinous Ovarian Cancer
OncoTree Code
MOV

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.