Overview

NCI Definition: A malignant mixed epithelial neoplasm that arises from the ovary and is composed predominantly of serous and endocervical-type mucinous epithelium. [1]

Ovarian seromucinous carcinomas most frequently harbor alterations in KRAS, TP53, SRSF2, PIK3CA, and CDKN2A [2].

Most Commonly Altered Genes in Ovarian Seromucinous Carcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, TP53 Mutation, and PIK3CA Mutation are the most common alterations in ovarian seromucinous carcinoma [2].

Top Alterations in Ovarian Seromucinous Carcinoma

Disease Details

Synonyms
Malignant Ovarian Mixed Epithelial Tumor, Ovarian Mixed Epithelial Carcinoma, Malignant Ovarian Mixed Epithelial Neoplasm, Mixed Epithelial Carcinoma of Ovary, Mixed Epithelial Carcinoma of the Ovary
Parent(s)
Ovarian Seromucinous Tumor
OncoTree Name
Ovarian Seromucinous Carcinoma
OncoTree Code
OSMCA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.