Overview

NCI Definition: An adenocarcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that, in well differentiated tumors, resemble the epithelium of the fallopian tube or, in poorly differentiated tumors, show anaplastic features and marked nuclear atypia. [1]

Ovarian serous adenocarcinomas most frequently harbor alterations in TP53, KRAS, CCNE1, BRCA1, and NF1 [2].

Most Commonly Altered Genes in Ovarian Serous Adenocarcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, TP53 Frameshift, and TP53 Nonsense are the most common alterations in ovarian serous adenocarcinoma [2].

Top Alterations in Ovarian Serous Adenocarcinoma

Disease Details

Synonyms
Serous Carcinoma of the Ovary, Serous Adenocarcinoma of the Ovary, Ovarian Serous Carcinoma, Serous Carcinoma of Ovary, Ovary serous carcinoma, Serous Adenocarcinoma of Ovary
Parent(s)
Serous Adenocarcinoma
Children
Low Grade Ovarian Serous Adenocarcinoma, High Grade Ovarian Serous Adenocarcinoma, Ovarian Serous Surface Papillary Adenocarcinoma, and Ovarian Serous Cystadenocarcinoma
OncoTree Name
Serous Ovarian Cancer
OncoTree Code
SOC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.