Overview

Ovarian serous tumors most frequently harbor alterations in TP53, KRAS, CCNE1, BRCA1, and NF1 [2].

Most Commonly Altered Genes in Ovarian Serous Tumor

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, TP53 Frameshift, and TP53 Nonsense are the most common alterations in ovarian serous tumor [2].

Top Alterations in Ovarian Serous Tumor

Significant Genes in Ovarian Serous Tumor

ARID1A +

ATM +

ATRX +

BRCA1 +

BRCA2 +

DAXX +

TP53 +

Disease Details

Parent(s)
Ovarian Epithelial Tumor
Children
Borderline Ovarian Serous Tumor and Malignant Ovarian Serous Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.