Overview

Ovarian serous tumors most frequently harbor alterations in TP53, KRAS, CCNE1, BRCA1, and NF1 [2].

Most Commonly Altered Genes in Ovarian Serous Tumor

TP53 Mutation (somatic), TP53 Mutation (germline), TP53 Mutation, TP53 Missense (germline), and TP53 Missense are the most common alterations in ovarian serous tumor [2].

Top Alterations in Ovarian Serous Tumor

Significant Genes in Ovarian Serous Tumor

ARID1A +

ATM +

ATRX +

BRCA1 +

BRCA2 +

DAXX +

TP53 +

Disease Details

Parent(s)
Ovarian Epithelial Tumor
Children
Malignant Ovarian Serous Tumor and Borderline Ovarian Serous Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.