Ovarian Sex Cord Stromal Tumor
NCI Definition: A benign or malignant neoplasm that arises from the ovary and is composed of granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts. Representative examples include thecoma, fibroma, Sertoli cell tumor, and granulosa cell tumor. 
Ovarian sex cord stromal tumors most frequently harbor alterations in FOXL2, DICER1, KMT2D, PRKDC, and ATM .
FOXL2 Mutation, FOXL2 C134W, DICER1 Mutation, KMT2fs, and KMT2D Mutation are the most common alterations in ovarian sex cord stromal tumor .
There is 1 clinical trial for ovarian sex cord stromal tumor, of which 1 is open and 0 are completed or closed. Of the trial that contains ovarian sex cord stromal tumor as an inclusion criterion, 1 is phase 2 (1 open).
Nilotinib and paclitaxel are the most common interventions in ovarian sex cord stromal tumor clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.