Overview

NCI Definition: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. [1]

Disease Details

Synonyms
Islet Cell Carcinoma, Malignant Pancreatic Endocrine Tumor, CARCINOMA, ISLET CELL, MALIGNANT, Pancreatic NEC G3, Islet Cell Cancer, Pancreatic Endocrine Carcinoma, Pancreatic NEC, High Grade Pancreatic Neuroendocrine Carcinoma, pancreatic endocrine cancer, High-Grade Pancreatic Neuroendocrine Carcinoma, Malignant Islet Cell Tumor, Poorly Differentiated Pancreatic Endocrine Carcinoma, Pancreas neuroendocrine carcinoma
Parent(s)
Pancreatic Neuroendocrine Neoplasm
Children
Pancreatic Small Cell Neuroendocrine Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.