NCI Definition: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. [1]

Disease Details

Pancreatic NEC, High Grade Pancreatic Neuroendocrine Carcinoma, High-Grade Pancreatic Neuroendocrine Carcinoma, Islet Cell Cancer, Malignant Pancreatic Endocrine Tumor, Pancreatic Endocrine Carcinoma, Pancreatic NEC G3, CARCINOMA, ISLET CELL, MALIGNANT, Malignant Islet Cell Tumor, Islet Cell Carcinoma, Poorly Differentiated Pancreatic Endocrine Carcinoma, Pancreas neuroendocrine carcinoma, pancreatic endocrine cancer
Malignant Pancreatic Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.