Pancreatic Neuroendocrine Carcinoma
Associated Genetic Biomarkers
NCI Definition: An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. 
There are 4 clinical trials for pancreatic neuroendocrine carcinoma, of which 3 are open and 1 is completed or closed. Of the trials that contain pancreatic neuroendocrine carcinoma as an inclusion criterion, 4 are phase 2 (3 open).
ER and PR are the most frequent gene inclusion criteria for pancreatic neuroendocrine carcinoma clinical trials .
Etoposide, ipilimumab, and nilotinib are the most common interventions in pancreatic neuroendocrine carcinoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.