NCI Definition: A neoplasm with neuroendocrine differentiation that arises from the pancreas. It includes neuroendocrine tumors (low and intermediate grade) and neuroendocrine carcinomas (high grade). [1]

Pancreatic neuroendocrine neoplasms most frequently harbor alterations in MEN1, DAXX, ATRX, TP53, and TSC2 [2].

Most Commonly Altered Genes in Pancreatic Neuroendocrine Neoplasm

DAXX Mutation, MEN1 Mutation, MEN1fs, ATRX Mutation, and TP53 Mutation are the most common alterations in pancreatic neuroendocrine neoplasm [2].

Top Alterations in Pancreatic Neuroendocrine Neoplasm

Significant Genes in Pancreatic Neuroendocrine Neoplasm


Disease Details

Pancreatic Endocrine Neoplasm
Pancreatic Neoplasm
Pancreatic Neuroendocrine Tumor and Pancreatic Neuroendocrine Carcinoma
OncoTree Name
Pancreatic Neuroendocrine Tumor
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.