Overview

NCI Definition: Also known as chromophil carcinoma, it represents a minority of renal cell carcinomas. It can be hereditary or sporadic. The sporadic papillary renal cell carcinoma is characterized by trisomy of chromosomes 7, 16, and 17, and loss of chromosome Y. The peak incidence is in the sixth and seven decades. It is classified as type 1 or 2, based on the cytoplasmic volume and the thickness of the lining neoplastic cells. The prognosis is more favorable than for conventional (clear cell) renal cell carcinoma. -- 2003 [1]

Significant Genes in Papillary Renal Cell Carcinoma

FH +

IDH1 +

IDH2 +

KRAS +

MET +

MYC +

SDHA +

SDHB +

SDHC +

SDHD +

TFE3 +

TSC1 +

Disease Details

Synonyms
Chromophil Renal Cell Carcinoma, Chromophil Carcinoma of Kidney, Chromophil Carcinoma of the Kidney, Kidney renal papillary carcinoma, Papillary (Chromophil) Renal Cell Carcinoma
Parent(s)
Papillary Adenocarcinoma
Children
Hereditary Papillary Renal Cell Carcinoma
OncoTree Name
Papillary Renal Cell Carcinoma
OncoTree Code
PRCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.