Overview

NCI Definition: A malignant tumor arising from the parenchymal cells of the parathyroid gland. It is associated with the symptoms of primary hyperparathyroidism, resulting from the excessive production of parathyroid hormone. Morphologically, the differential diagnosis from parathyroid gland adenoma may be difficult. A definitive diagnosis of carcinoma is made only in the presence of capsular invasion, vascular invasion, and/or perineural invasion. [1]

Parathyroid gland carcinomas most frequently harbor alterations in BRAF, NRAS, ZFHX3, RET, and PTEN [2].

Most Commonly Altered Genes in Parathyroid Gland Carcinoma

BRAF V600E, BRAF Mutation, BRAF Exon 15 Mutation, BRAF Codon 600 Missense, and NRAS Q61R are the most common alterations in parathyroid gland carcinoma [2].

Top Alterations in Parathyroid Gland Carcinoma

Disease Details

Synonyms
Adenocarcinoma of the Parathyroid, Parathyroid Gland Cancer, Adenocarcinoma of Parathyroid Gland, Adenocarcinoma of the Parathyroid Gland, Carcinoma of Parathyroid Gland, Carcinoma of Parathyroid, Cancer of the Parathyroid Gland, Parathyroid Adenocarcinoma, Parathyroid Carcinoma, Parathyroid Cancer, Carcinoma of the Parathyroid Gland, Parathyroid cancer, NOS, Cancer of Parathyroid Gland, parathyroid cancer, Parathyroid Gland Adenocarcinoma, Adenocarcinoma of Parathyroid, Carcinoma of the Parathyroid
Parent(s)
Parathyroid Gland Neoplasm
OncoTree Name
Parathyroid Carcinoma
OncoTree Code
PTHC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.