Overview

NCI Definition: A benign or malignant mesothelial neoplasm that arises from the peritoneum. [1]

Peritoneal mesotheliomas most frequently harbor alterations in BAP1, SETD2, TP53, NF2, and CDKN2B [2].

Most Commonly Altered Genes in Peritoneal Mesothelioma

BAP1 Mutation, BAP1 Loss, TP53 Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in peritoneal mesothelioma [2].

Top Alterations in Peritoneal Mesothelioma

Significant Genes in Peritoneal Mesothelioma

AKT1 +

AKT2 +

AKT3 +

CRKL +

EGFR +

ERBB2 +

FH +

IDH1 +

IDH2 +

IRS2 +

KIT +

KRAS +

MET +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

MTOR +

MYC +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PMS1 +

PMS2 +

PTEN +

RICTOR +

RNF43 +

RPTOR +

SDHA +

SDHB +

SDHC +

SDHD +

TSC1 +

TSC2 +

Disease Details

Synonyms
Mesothelioma of Peritoneum, Peritoneum mesothelioma, Mesothelioma of the Peritoneum
Parent(s)
Mesothelioma
Children
Peritoneal Malignant Mesothelioma
OncoTree Name
Peritoneal Mesothelioma
OncoTree Code
PEMESO

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.