Diseases /
Pineoblastoma
Overview
NCI Definition: A poorly differentiated malignant embryonal neoplasm arising from the pineal region. It usually occurs in children and it is characterized by the presence of small immature neuroepithelial cells. It may follow an aggressive clinical course. [1]
Pineoblastomas most frequently harbor alterations in EPHB1, DICER1, CDK12, ATR, and ATM [2].
EPHB1 V205E, EPHB1 Mutation, CDK12 P1091S, CDK12 Mutation, and ATR Mutation are the most common alterations in pineoblastoma [2].
Clinical Trials
Significant Genes in Pineoblastoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.