Diseases /
Pituitary Gland Carcinoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A rare adenocarcinoma with poor prognosis, arising from the adenohypophysial cells of the anterior lobe of the pituitary gland or pre-existing adenomas. The majority are hormonally functioning neoplasms, usually producing prolactin or ACTH. The diagnosis is based on the presence of metastases. Syndromes associated with pituitary gland carcinomas include hyperprolactinemia, Cushing disease, and acromegaly. [1]
Pituitary gland carcinomas most frequently harbor alterations in WWTR1, TMPRSS2, STAG2, SPEN, and RNF43 [2].
WWTR1 Q232_Q233dup, TMPRSS2 G313R, STAG2fs, SPEN T2685I, and RNF43 R219C are the most common alterations in pituitary gland carcinoma [2].
Clinical Trials
Significant Genes in Pituitary Gland Carcinoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.