Overview

NCI Definition: A benign or malignant neoplasm affecting the pituitary gland. The vast majority are adenomas arising from the anterior lobe of the pituitary gland. [1]

Pituitary gland neoplasms most frequently harbor alterations in GNAS, PRKDC, ARID1B, PTPRD, and FANCA [2].

Most Commonly Altered Genes in Pituitary Gland Neoplasm

GNAS Mutation, PRKDC Mutation, ARID1B Mutation, FANCA Mutation, and KMT2D Mutation are the most common alterations in pituitary gland neoplasm [2].

Top Alterations in Pituitary Gland Neoplasm

Disease Details

Synonyms
Neoplasm of Pituitary, Tumor of Pituitary Gland, Pituitary Gland Tumor, Tumor of the Pituitary Gland, Tumor of Pituitary, Pituitary Tumor, Pituitary Neoplasm, Neoplasm of Pituitary Gland, Tumor of the Pituitary, Neoplasm of the Pituitary Gland, Neoplasm of the Pituitary
Parent(s)
Supratentorial Neoplasm
Children
Posterior Pituitary Gland Neoplasm, Malignant Pituitary Gland Neoplasm, and Anterior Pituitary Gland Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.