Overview

NCI Definition: An aggressive plasma cell neoplasm characterized by the presence of neoplastic plasma cells in the peripheral blood. It is characterized by the presence of a circulating clonal plasma cell count that exceeds 2x10^9/L or is 20% of the leukocyte differential count. [1]

Significant Genes in Plasma Cell Leukemia

ABL1 +

AFF1 +

ASXL1 +

BCL2 +

BCL6 +

BCR +

CALR +

CCND1 +

CCND3 +

DEK +

ELL +

EZH2 +

FGFR3 +

FLT3 +

IDH1 +

IDH2 +

IGH +

IKZF1 +

JAK2 +

KMT2A +

MAF +

MAFB +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MPL +

MYC +

NPM1 +

NUP214 +

PBX1 +

RPN1 +

SRSF2 +

TCF3 +

TP53 +

WHSC1 +

Disease Details

Synonyms
Leukemia Plasmacytic, Plasmacytic Leukemia
Parent(s)
Plasma Cell Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.