Overview

NCI Definition: A clonal proliferation of immunoglobulin-secreting plasma cells. This category includes plasma cell myeloma, plasma cell leukemia, plasmacytoma, monoclonal immunoglobulin deposition disease, and monoclonal gammopathy of undetermined significance. [1]

Significant Genes in Plasma Cell Neoplasm

ABL1 +

AFF1 +

BCR +

DEK +

ELL +

FLT3 +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NUP214 +

PBX1 +

RPN1 +

TCF3 +

TP53 +

Disease Details

Synonyms
Plasma Cell Dyscrasia, Plasmacytic Tumor, Plasmacytic Tumour, Plasmacytic Neoplasm, PLASMA CELL TUMOR, MALIGNANT, Plasma Cell Tumor
Parent(s)
Mature B-Cell Neoplasm
Children
Plasmacytoma, Multiple Myeloma, Plasma Cell Leukemia, Non-IgM Monoclonal Gammopathy of Undetermined Significance, and Monoclonal Immunoglobulin Deposition Disease

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.