Overview

NCI Definition: A clonal proliferation of immunoglobulin-secreting plasma cells. This category includes plasma cell myeloma, plasma cell leukemia, plasmacytoma, monoclonal immunoglobulin deposition disease, and monoclonal gammopathy of undetermined significance. [1]

Plasma cell neoplasms most frequently harbor alterations in KRAS, TP53, NRAS, TET2, and DNMT3A [2].

Most Commonly Altered Genes in Plasma Cell Neoplasm

KRAS Mutation, TP53 Mutation, NRAS Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in plasma cell neoplasm [2].

Top Alterations in Plasma Cell Neoplasm

Significant Genes in Plasma Cell Neoplasm

ABL1 +

AFF1 +

BCR +

DEK +

ELL +

FLT3 +

KMT2A +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NRIP3 +

NUP214 +

PBX1 +

RPN1 +

TCF3 +

TP53 +

Disease Details

Synonyms
Plasma Cell Dyscrasia, Plasma Cell Disorder, Plasma Cell Tumor, PLASMA CELL TUMOR, MALIGNANT, Plasmacytic Tumor, Plasmacytic Neoplasm, Plasmacytic Tumour
Parent(s)
Mature B-Cell Neoplasm
Children
Plasma Cell Leukemia, Monoclonal Immunoglobulin Deposition Disease, Plasmacytoma, Multiple Myeloma, and Non-IgM Monoclonal Gammopathy of Undetermined Significance

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.