Associated Genetic Biomarkers
NCI Definition: A liposarcoma characterized by the presence of varying proportions of pleomorphic lipoblasts in a background that resembles undifferentiated pleomorphic sarcoma. It is the rarest liposarcoma variant and usually has an aggressive clinical course. 
Pleomorphic liposarcomas most frequently harbor alterations in TP53 and RB1 .
TP53 Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in pleomorphic liposarcoma .
There are 3 clinical trials for pleomorphic liposarcoma, of which 3 are open and 0 are completed or closed. Of the trials that contain pleomorphic liposarcoma as an inclusion criterion, 3 are phase 2 (3 open).
PIK3CA and PTEN are the most frequent gene inclusion criteria for pleomorphic liposarcoma clinical trials .
Bempegaldesleukin, nivolumab, and pembrolizumab are the most common interventions in pleomorphic liposarcoma clinical trials.
Significant Genes in Pleomorphic Liposarcoma
PIK3CA is an inclusion eligibility criterion in 1 clinical trial for pleomorphic liposarcoma, of which 1 is open and 0 are closed. Of the trial that contains PIK3CA status and pleomorphic liposarcoma as inclusion criteria, 1 is phase 2 (1 open) .
PTEN is an inclusion eligibility criterion in 1 clinical trial for pleomorphic liposarcoma, of which 1 is open and 0 are closed. Of the trial that contains PTEN status and pleomorphic liposarcoma as inclusion criteria, 1 is phase 2 (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.