Overview

NCI Definition: Malignant mesothelioma that arises from the pleura. It is characterized by the presence of epithelioid and sarcomatoid components, with each component representing at least 10% of the tumor. [1]

Pleural biphasic mesotheliomas most frequently harbor alterations in BAP1, CDKN2A, NF2, CDKN2B, and TP53 [2].

Most Commonly Altered Genes in Pleural Biphasic Mesothelioma

CDKN2A Loss, NF2 Mutation, CDKN2B Loss, BAP1 Mutation, and NF2 Frameshift are the most common alterations in pleural biphasic mesothelioma [2].

Top Alterations in Pleural Biphasic Mesothelioma

Disease Details

Parent(s)
Malignant Pleural Mesothelioma
OncoTree Name
Pleural Mesothelioma, Biphasic Type
OncoTree Code
PLBMESO

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.