Overview

NCI Definition: Malignant mesothelioma that arises from the pleura and is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns. [1]

Pleural epithelioid mesotheliomas most frequently harbor alterations in BAP1, CDKN2A, NF2, CDKN2B, and SETD2 [2].

Most Commonly Altered Genes in Pleural Epithelioid Mesothelioma

BAP1 Mutation, CDKN2A Loss, CDKN2B Loss, NF2 Mutation, and SETD2 Mutation are the most common alterations in pleural epithelioid mesothelioma [2].

Top Alterations in Pleural Epithelioid Mesothelioma

Disease Details

Parent(s)
Malignant Pleural Mesothelioma
OncoTree Name
Pleural Mesothelioma, Epithelioid Type
OncoTree Code
PLEMESO

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.