Overview

NCI Definition: Malignant mesothelioma that arises from the pleura and is characterized by the presence of spindle-shaped cells forming fascicles, or that are distributed haphazardly resembling a sarcoma. [1]

Pleural mesothelioma, sarcomatoid types most frequently harbor alterations in NF2, CDKN2A, and CDKN2B [2].

Most Commonly Altered Genes in Pleural Mesothelioma, Sarcomatoid Type

NF2 Mutation, CDKN2A Loss, NF2 Nonsense, and CDKN2B Loss are the most common alterations in pleural mesothelioma, sarcomatoid type [2].

Top Alterations in Pleural Mesothelioma, Sarcomatoid Type

Disease Details

Parent(s)
Sarcomatoid Mesothelioma
OncoTree Name
Pleural Mesothelioma, Sarcomatoid Type
OncoTree Code
PLSMESO

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.