Overview

NCI Definition: Malignant mesothelioma that arises from the pleura and is characterized by the presence of spindle-shaped cells forming fascicles, or that are distributed haphazardly resembling a sarcoma. [1]

Pleural mesothelioma, sarcomatoid types most frequently harbor alterations in NF2, CDKN2A, CDKN2B, BAP1, and TP53 [2].

CDKN2A Loss, CDKN2B Loss, NF2 Nonsense, NF2 Mutation, and TP53 Mutation are the most common alterations in pleural mesothelioma, sarcomatoid type [2].

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.