Overview

NCI Definition: A neoplasm that arises from the mesothelial cells of the pleura. The primary cause is exposure to asbestos. The major histologic variants are the epithelioid malignant mesothelioma, desmoplastic malignant mesothelioma, and sarcomatoid malignant mesothelioma. Patients present with persistent cough and shortness of breath. [1]

Significant Genes in Pleural Mesothelioma

ARID1A +

BAP1 +

FH +

IDH1 +

IDH2 +

KRAS +

MYC +

SDHA +

SDHB +

SDHC +

SDHD +

Disease Details

Synonyms
Mesothelioma of Pleura, Pleura mesothelioma, Mesothelioma of the Pleura
Parent(s)
Pleural Neoplasm
Children
Malignant Pleural Mesothelioma
OncoTree Name
Pleural Mesothelioma
OncoTree Code
PLMESO

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.