Overview

NCI Definition: A neoplasm that arises from the mesothelial cells of the pleura. The primary cause is exposure to asbestos. The major histologic variants are the epithelioid malignant mesothelioma, desmoplastic malignant mesothelioma, and sarcomatoid malignant mesothelioma. Patients present with persistent cough and shortness of breath. [1]

Pleural mesotheliomas most frequently harbor alterations in BAP1, CDKN2A, NF2, CDKN2B, and TP53 [2].

Most Commonly Altered Genes in Pleural Mesothelioma

BAP1 Mutation, CDKN2A Loss, NF2 Mutation, CDKN2B Loss, and SETD2 Mutation are the most common alterations in pleural mesothelioma [2].

Top Alterations in Pleural Mesothelioma

Significant Genes in Pleural Mesothelioma

ERBB2 +

FH +

IDH1 +

IDH2 +

KRAS +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

MYC +

PMS1 +

PMS2 +

SDHA +

SDHB +

SDHC +

SDHD +

Disease Details

Synonyms
Mesothelioma of the Pleura, Pleura mesothelioma, Mesothelioma of Pleura
Parent(s)
Pleural Neoplasm
Children
Malignant Pleural Mesothelioma
OncoTree Name
Pleural Mesothelioma
OncoTree Code
PLMESO

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.