Associated Genetic Biomarkers
NCI Definition: An elongated and multinodular neurofibroma, formed when the tumor involves either multiple trunks of a plexus or multiple fascicles of a large nerve, such as the sciatic. Some plexiform neurofibromas resemble a bag of worms, others produce a massive ropy enlargement of the nerve. (Adapted from WHO.) 
There are 6 clinical trials for plexiform neurofibroma, of which 5 are open and 1 is completed or closed. Of the trials that contain plexiform neurofibroma as an inclusion criterion, 2 are phase 1 (2 open), 1 is phase 1/phase 2 (1 open), and 3 are phase 2 (2 open).
NF1 is the most frequent gene inclusion criterion for plexiform neurofibroma clinical trials .
Selumetinib, binimetinib, and imatinib are the most common interventions in plexiform neurofibroma clinical trials.
Significant Genes in Plexiform Neurofibroma
NF1 is an inclusion eligibility criterion in 4 clinical trials for plexiform neurofibroma, of which 4 are open and 0 are closed. Of the trials that contain NF1 status and plexiform neurofibroma as inclusion criteria, 1 is phase 1 (1 open), 1 is phase 1/phase 2 (1 open), and 2 are phase 2 (2 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.