Primary Cutaneous Anaplastic Large Cell Lymphoma
Associated Genetic Biomarkers
NCI Definition: An anaplastic large cell lymphoma limited to the skin at the time of diagnosis. Most patients present with solitary or localized skin lesions, which may be tumors, nodules or papules. The t(2;5) translocation that is present in many cases of systemic anaplastic large cell lymphoma, is not found in this disease. (WHO, 2001) 
There are 3 clinical trials for primary cutaneous anaplastic large cell lymphoma, of which 3 are open and 0 are completed or closed. Of the trials that contain primary cutaneous anaplastic large cell lymphoma as an inclusion criterion, 1 is phase 1 (1 open) and 2 are phase 2 (2 open).
TNFRSF8 is the most frequent gene inclusion criterion for primary cutaneous anaplastic large cell lymphoma clinical trials .
Autologous ccr4-cd30car-cd28-cd3zeta-expressing t-lymphocytes, autologous cd30car-cd28-cd3zeta-expressing t-lymphocytes, and azacitidine are the most common interventions in primary cutaneous anaplastic large cell lymphoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.