Primary Cutaneous Follicle Center Lymphoma
Associated Genetic Biomarkers
NCI Definition: A primary lymphoma of the skin composed of various numbers of small and large irregular neoplastic follicle center cells. Its morphologic pattern can be nodular, diffuse, or nodular and diffuse. It presents with solitary or grouped plaques and tumors, and it usually involves the scalp, forehead, or trunk. It rarely involves the legs. This type of cutaneous lymphoma tends to remain localized to the skin. 
There are 2 clinical trials for primary cutaneous follicle center lymphoma, of which 2 are open and 0 are completed or closed. Of the trials that contain primary cutaneous follicle center lymphoma as an inclusion criterion, 1 is phase 1 (1 open) and 1 is phase 2 (1 open).
TNFRSF8 is the most frequent gene inclusion criterion for primary cutaneous follicle center lymphoma clinical trials .
Bms 986178, sd-101, and leflunomide are the most common interventions in primary cutaneous follicle center lymphoma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.