Overview

NCI Definition: A T-cell non-Hodgkin lymphoma arising from the skin. Representative examples include mycosis fungoides and primary cutaneous anaplastic large cell lymphoma. [1]

Primary cutaneous T cell non-hodgkin lymphomas most frequently harbor alterations in KMT2D, CDKN2A, CDKN2B, ARID1A, and TET2 [2].

Most Commonly Altered Genes in Primary Cutaneous T Cell Non-Hodgkin Lymphoma

KMT2D Mutation, CDKN2A Loss, CDKN2B Loss, TET2 Mutation, and ARID1A Mutation are the most common alterations in primary cutaneous T cell non-hodgkin lymphoma [2].

Top Alterations in Primary Cutaneous T Cell Non-Hodgkin Lymphoma

Significant Genes in Primary Cutaneous T Cell Non-Hodgkin Lymphoma

ETV6 +

IRAK1 +

JAK2 +

JAK3 +

MYD88 +

TYK2 +

Disease Details

Synonyms
Cutaneous T-Cell Lymphoma
Parent(s)
Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
Children
Primary Cutaneous Gamma-Delta T-Cell Lymphoma, Mycosis Fungoides, Primary Cutaneous Anaplastic Large Cell Lymphoma, Subcutaneous Panniculitis-Like T-Cell Lymphoma, Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma, and Primary Cutaneous Acral CD8-Positive T-Cell Lymphoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.