Diseases /

Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Back to Diseases List

Overview

NCI Definition: A diffuse large B-cell lymphoma arising from the central nervous system. [1]

Primary diffuse large B-cell lymphoma of the central nervous systems most frequently harbor alterations in SETD1B, PIM1, MYD88, ETV6, and U2AF2 [2].

Most Commonly Altered Genes in Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

PIM1 Mutation, MYD88 Mutation, MYD88 L265P, MYD88 Exon 5 Mutation, and ETV6 X11_splice are the most common alterations in primary diffuse large B-cell lymphoma of the central nervous system [2].

Top Alterations in Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Clinical Trials

View Clinical Trials for Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System

Disease Details

Synonyms
CNS DLBCL, Central Nervous System Diffuse Large B-Cell Lymphoma, Primary DLBCL of the CNS
Parent(s)
Diffuse Large B-Cell Lymphoma
OncoTree Name
Primary DLBCL of the central nervous system
OncoTree Code
PCNSL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.