Overview

Primary mediastinal B-cell lymphomas most frequently harbor alterations in SOCS1, TNFAIP3, XPO1, CIITA, and STAT6 [2].

Most Commonly Altered Genes in Primary Mediastinal B-Cell Lymphoma

SOCS1fs, XPO1 Mutation, XPO1 E571K, TNFAIP3fs, and STAT6 Mutation are the most common alterations in primary mediastinal B-cell lymphoma [2].

Top Alterations in Primary Mediastinal B-Cell Lymphoma

Significant Genes in Primary Mediastinal B-Cell Lymphoma

ALK +

BCL2 +

BCL6 +

CCND1 +

IGH +

IRF4 +

MYC +

Disease Details

Synonyms
PMBCL, Lymph node lymphoma mediastinal B-cell (PMBCL)
Parent(s)
Mediastinal Lymphoma
Children
Mediastinal Large B-Cell Lymphoma, Mediastinal B-Cell Lymphoma, Unclassifiable, with Features Intermediate between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma, and Thymic Mucosa-Associated Lymphoid Tissue Lymphoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.