Overview

NCI Definition: A rare adenocarcinoma that arises from the lining of the peritoneum. [1]

Primary peritoneal adenocarcinomas most frequently harbor alterations in TP53, KRAS, EPHB1, BRCA2, and BCOR [2].

Most Commonly Altered Genes in Primary Peritoneal Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53fs, and TP53 Exon 8 Mutation are the most common alterations in primary peritoneal adenocarcinoma [2].

Top Alterations in Primary Peritoneal Adenocarcinoma

Disease Details

Synonyms
Primary adenocarcinoma of peritoneum
Parent(s)
Adenocarcinoma
Children
Primary Peritoneal Clear Cell Carcinoma, Primary Peritoneal Endometrioid Adenocarcinoma, and Primary Peritoneal Serous Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.