Overview

NCI Definition: A rare, serous adenocarcinoma that arises from the lining of the peritoneum. It affects females. The clinical behavior and pathologic characteristics are similar to the serous adenocarcinoma that arises from the ovary. [1]

Primary peritoneal serous adenocarcinomas most frequently harbor alterations in TP53, KRAS, EPHB1, BRCA2, and BCOR [2].

Most Commonly Altered Genes in Primary Peritoneal Serous Adenocarcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53fs, and TP53 Exon 8 Mutation are the most common alterations in primary peritoneal serous adenocarcinoma [2].

Top Alterations in Primary Peritoneal Serous Adenocarcinoma

Significant Genes in Primary Peritoneal Serous Adenocarcinoma

BRCA1 +

BRCA2 +

ERBB2 +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

TP53 +

Disease Details

Synonyms
Peritoneum serous carcinoma, Peritoneal Serous Carcinoma
Parent(s)
Serous Adenocarcinoma
Children
Primary Peritoneal High Grade Serous Adenocarcinoma, Primary Peritoneal Low Grade Serous Adenocarcinoma, and Primary Peritoneal Serous Papillary Adenocarcinoma
OncoTree Name
Peritoneal Serous Carcinoma
OncoTree Code
PSEC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.