Overview

NCI Definition: A mature B- or T- cell leukemia with progressive clinical course. It is characterized by the presence of medium-sized lymphocytes with visible nucleoli (prolymphocytes) in the peripheral blood, bone marrow, and spleen. [1]

Significant Genes in Prolymphocytic Leukemia

ABL1 +

AFF1 +

ATM +

BCR +

BIRC3 +

CBFB +

DEK +

ELL +

FGFR3 +

FLT3 +

IGH +

IKZF1 +

KIT +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYH11 +

NPM1 +

NUP214 +

PBX1 +

RPN1 +

RUNX1 +

RUNX1T1 +

SF3B1 +

TCF3 +

TP53 +

WHSC1 +

Disease Details

Synonyms
PLL, Prolymphocytic leukemia (B or T-cell), Prolymphocytic leukemia (B or T)
Parent(s)
Lymphoid Leukemia
Children
B-Cell Prolymphocytic Leukemia and T-Cell Prolymphocytic Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.