NCI Definition: A benign, borderline, or malignant neoplasm that affects the prostate gland. Representative examples include benign prostate phyllodes tumor, prostatic intraepithelial neoplasia, prostate carcinoma, and prostate sarcoma. [1]

Prostate neoplasms most frequently harbor alterations in TP53, TMPRSS2, ERG, PTEN, and AR [2].

Most Commonly Altered Genes in Prostate Neoplasm

TP53 Mutation, TMPRSS2-ERG Fusion, TP53 Missense, TP53 c.217-c.1178 Missense, and AR Amplification are the most common alterations in prostate neoplasm [2].

Top Alterations in Prostate Neoplasm

Disease Details

Neoplasm of Prostate, Prostate Tumor, Neoplasm of the Prostate, Tumor of the Prostate, Tumor of Prostate
Prostate Disorder
Malignant Prostate Neoplasm, Grade III Prostatic Intraepithelial Neoplasia, Prostate Neuroendocrine Neoplasm, Prostate Leiomyoma, Benign Prostate Phyllodes Tumor, and Prostate Adenoma
OncoTree Name
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.