Overview

NCI Definition: A benign, borderline, or malignant neoplasm that affects the prostate gland. Representative examples include benign prostate phyllodes tumor, prostatic intraepithelial neoplasia, prostate carcinoma, and prostate sarcoma. [1]

Prostate neoplasms most frequently harbor alterations in TP53, TMPRSS2, ERG, PTEN, and AR [2].

Most Commonly Altered Genes in Prostate Neoplasm

TP53 Mutation, TMPRSS2-ERG Fusion, TP53 Missense, TP53 c.217-c.1178 Missense, and AR Amplification are the most common alterations in prostate neoplasm [2].

Top Alterations in Prostate Neoplasm

Disease Details

Synonyms
Neoplasm of Prostate, Tumor of the Prostate, Neoplasm of the Prostate, Prostate Tumor, Tumor of Prostate
Parent(s)
Prostate Disorder
Children
Benign Prostate Phyllodes Tumor, Grade III Prostatic Intraepithelial Neoplasia, Prostate Adenoma, Prostate Leiomyoma, Prostate Neuroendocrine Neoplasm, and Malignant Prostate Neoplasm
OncoTree Name
Prostate
OncoTree Code
PROSTATE

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.