Overview

NCI Definition: A small cell or rarely a large cell neuroendocrine carcinoma that arises from the prostate gland. [1]

Prostate neuroendocrine carcinomas most frequently harbor alterations in TP53, RB1, TMPRSS2, PTEN, and ERG [2].

Most Commonly Altered Genes in Prostate Neuroendocrine Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, RB1 Loss, and TP53 Loss are the most common alterations in prostate neuroendocrine carcinoma [2].

Top Alterations in Prostate Neuroendocrine Carcinoma

Disease Details

Parent(s)
Prostate Neuroendocrine Neoplasm
Children
Prostate Small Cell Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.