NCI Definition: A small cell or rarely a large cell neuroendocrine carcinoma that arises from the prostate gland. [1]

Prostate neuroendocrine carcinomas most frequently harbor alterations in RB1, TP53, TMPRSS2, ERG, and PTEN [2].

Most Commonly Altered Genes in Prostate Neuroendocrine Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, RB1 Loss, and TMPRSS2-ERG Fusion are the most common alterations in prostate neuroendocrine carcinoma [2].

Top Alterations in Prostate Neuroendocrine Carcinoma

Disease Details

Prostate Neuroendocrine Neoplasm
Prostate Small Cell Carcinoma
OncoTree Name
Prostate Neuroendocrine Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.