Overview

NCI Definition: A neoplasm with neuroendocrine differentiation that arises from the prostate gland. This category includes carcinoid tumors and small cell carcinomas. [1]

Prostate neuroendocrine neoplasms most frequently harbor alterations in TP53, RB1, TMPRSS2, PTEN, and ERG [2].

Most Commonly Altered Genes in Prostate Neuroendocrine Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, RB1 Loss, and TP53 Loss are the most common alterations in prostate neuroendocrine neoplasm [2].

Top Alterations in Prostate Neuroendocrine Neoplasm

Disease Details

Synonyms
Neuroendocrine Neoplasm of Prostate, Neuroendocrine Neoplasm of the Prostate
Parent(s)
Neuroendocrine Neoplasm
Children
Prostate Neuroendocrine Carcinoma
OncoTree Name
Prostate Neuroendocrine Carcinoma
OncoTree Code
PRNE

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.