NCI Definition: A neoplasm with neuroendocrine differentiation that arises from the prostate gland. This category includes carcinoid tumors and small cell carcinomas. [1]

Prostate neuroendocrine neoplasms most frequently harbor alterations in TP53, RB1, TMPRSS2, ERG, and PTEN [2].

Most Commonly Altered Genes in Prostate Neuroendocrine Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TMPRSS2-ERG Fusion, and RB1 Loss are the most common alterations in prostate neuroendocrine neoplasm [2].

Top Alterations in Prostate Neuroendocrine Neoplasm

Disease Details

Neuroendocrine Neoplasm of the Prostate, Neuroendocrine Neoplasm of Prostate
Prostate Neoplasm
Prostate Neuroendocrine Carcinoma and Prostate Well Differentiated Neuroendocrine Tumor


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.