Overview

NCI Definition: A neuroendocrine carcinoma of the prostate gland with unfavorable prognosis, composed of small cells containing neurosecretory granules. Approximately half of the cases show a mixture of small cells and adenocarcinoma cells. [1]

Prostate small cell carcinomas most frequently harbor alterations in RB1, TP53, TMPRSS2, and ERG [2].

Most Commonly Altered Genes in Prostate Small Cell Carcinoma

RB1 Loss, TP53 c.217-c.1178 Missense, TP53 Mutation, and TP53 Missense are the most common alterations in prostate small cell carcinoma [2].

Top Alterations in Prostate Small Cell Carcinoma

Significant Genes in Prostate Small Cell Carcinoma

CDK12 +

MLH3 +

PMS1 +

Disease Details

Synonyms
Oat Cell Carcinoma of Prostate, Oat Cell Carcinoma of the Prostate, Prostate Small Cell Neuroendocrine Carcinoma, Small Cell Carcinoma of Prostate, Prostate Small Cell NEC, Prostate Oat Cell Carcinoma, Small Cell Carcinoma of the Prostate
Parent(s)
Small Cell Carcinoma
OncoTree Name
Prostate Small Cell Carcinoma
OncoTree Code
PRSCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.