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Prostate Small Cell Carcinoma

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Associated Genetic Biomarkers

Overview

NCI Definition: A neuroendocrine carcinoma of the prostate gland with unfavorable prognosis, composed of small cells containing neurosecretory granules. Approximately half of the cases show a mixture of small cells and adenocarcinoma cells. [1]

Prostate small cell carcinomas most frequently harbor alterations in RB1, TP53, TMPRSS2, ERG, and PTEN [2].

Most Commonly Altered Genes in Prostate Small Cell Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, RB1 Loss, and TMPRSS2-ERG Fusion are the most common alterations in prostate small cell carcinoma [2].

Top Alterations in Prostate Small Cell Carcinoma

Clinical Trials

View Clinical Trials for Prostate Small Cell Carcinoma

Significant Genes in Prostate Small Cell Carcinoma

CD274 +

CDK12 +

MLH3 +

PMS1 +

Disease Details

Synonyms
Prostate Small Cell NEC, Prostate Oat Cell Carcinoma, Small Cell Carcinoma of the Prostate, Prostate Small Cell Neuroendocrine Carcinoma, Oat Cell Carcinoma of the Prostate, Oat Cell Carcinoma of Prostate, Small Cell Carcinoma of Prostate
Parent(s)
Small Cell Carcinoma
OncoTree Name
Prostate Small Cell Carcinoma
OncoTree Code
PRSCC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.