Overview

NCI Definition: An invasive prostate carcinoma characterized by the presence of squamous differentiation of the malignant cellular infiltrate. There is no evidence of glandular differentiation. [1]

Prostate squamous cell carcinomas most frequently harbor alterations in TP53, SPEN, REL, PIK3CA, and NFE2L2 [2].

TP53fs, SPEN V879G, REL P450S, PIK3CA Mutation, and PIK3CA E545K are the most common alterations in prostate squamous cell carcinoma [2].

Significant Genes in Prostate Squamous Cell Carcinoma

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.