NCI Definition: An invasive prostate carcinoma characterized by the presence of squamous differentiation of the malignant cellular infiltrate. There is no evidence of glandular differentiation. [1]

Prostate squamous cell carcinomas most frequently harbor alterations in TP53, SPEN, REL, PIK3CA, and NFE2L2 [2].

Most Commonly Altered Genes in Prostate Squamous Cell Carcinoma

TP53fs, SPEN V879G, REL P450S, PIK3CA Mutation, and PIK3CA E545K are the most common alterations in prostate squamous cell carcinoma [2].

Top Alterations in Prostate Squamous Cell Carcinoma

Significant Genes in Prostate Squamous Cell Carcinoma

CD274 +

Disease Details

Squamous Cell Carcinoma of Prostate, Squamous Cell Carcinoma of the Prostate
Squamous Cell Carcinoma
OncoTree Name
Prostate Squamous Cell Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.