Associated Genetic Biomarkers
NCI Definition: A very rare congenital disorder characterized by the development of multiple cutaneous and subcutaneous lesions including lipomas, nevi, and vascular malformations, associated with partial gigantism or digital overgrowth. 
There is 1 clinical trial for proteus syndrome, of which 1 is open and 0 are completed or closed. Of the trial that contains proteus syndrome as an inclusion criterion, 1 is phase 1/phase 2 (1 open).
PTEN is the most frequent gene inclusion criterion for proteus syndrome clinical trials .
Everolimus and placebo are the most common interventions in proteus syndrome clinical trials.
Significant Genes in Proteus Syndrome
PTEN is an inclusion eligibility criterion in 1 clinical trial for proteus syndrome, of which 1 is open and 0 are closed. Of the trial that contains PTEN status and proteus syndrome as inclusion criteria, 1 is phase 1/phase 2 (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.