Associated Genetic Biomarkers


NCI Definition: A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the rectum. [1]

Rectal neuroendocrine tumors most frequently harbor alterations in SF3B1, FLT4, USP9X, SETD2, and ROS1 [2].

Most Commonly Altered Genes in Rectal Neuroendocrine Tumor

SF3B1 Mutation, FLT4 Mutation, SETD2 Mutation, ROS1 Mutation, and NOTCH1 Mutation are the most common alterations in rectal neuroendocrine tumor [2].

Top Alterations in Rectal Neuroendocrine Tumor

Disease Details

Rectal Neuroendocrine Neoplasm
OncoTree Name
Well-Differentiated Neuroendocrine Tumor of the Rectum
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.