Overview

NCI Definition: A rhabdoid tumor that arises from the kidney. It occurs in children and it is associated with abnormalities of chromosome 22. It is characterized by the presence of cells with a large eccentric nucleus, prominent nucleolus, and abundant cytoplasm. The prognosis is poor. [1]

Significant Genes in Rhabdoid Tumor of the Kidney

MDM2 +

MDM4 +

PPM1D +

SMARCA4 +

SMARCB1 +

TET2 +

Disease Details

Synonyms
Kidney Rhabdoid Tumor, Malignant Rhabdoid Tumor of Kidney, Rhabdoid Tumor of the Kidney (RTK), MRTK, Rhabdoid Tumour of Kidney, Renal Rhabdoid Tumor, Renal Rhabdoid Neoplasm, Rhabdoid Neoplasm of Kidney, Rhabdoid Neoplasm of the Kidney, Rhabdoid Tumour of the Kidney, Malignant Rhabdoid Tumor of the Kidney
Parent(s)
Rhabdoid Tumor
OncoTree Name
Rhabdoid Cancer
OncoTree Code
MRT

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.