Overview

NCI Definition: A rare aggressive malignant mesenchymal neoplasm arising from skeletal muscle. It usually occurs in children and young adults. Only a small percentage of tumors arise in the skeletal muscle of the extremities. The majority arise in other anatomical sites. [1]

Significant Genes in Rhabdomyosarcoma

ABL1 +

AFF1 +

ATM +

ATR +

AXL +

BARD1 +

BCR +

BRCA1 +

BRCA2 +

BRIP1 +

CDK12 +

CHEK1 +

CHEK2 +

DEK +

EGFR +

ELL +

ERBB2 +

ERBB4 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FLT3 +

FOXO1 +

KMT2A +

MCPH1 +

MECOM +

MET +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MRE11A +

NBN +

NRIP3 +

NUP214 +

PALB2 +

PAX3 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RET +

RPN1 +

SLX4 +

TP53 +

Disease Details

Synonyms
RHABDOMYOSARCOMA, MALIGNANT, PEDIATRIC Soft tissue rhabdomyosarcoma (NOS), Soft tissue rhabdomyosarcoma (NOS), Rhabdomyosarcoma, NOS
Parent(s)
Soft Tissue Sarcoma
Children
Alveolar Rhabdomyosarcoma, Central Nervous System Rhabdomyosarcoma, Pleomorphic Rhabdomyosarcoma, Rectal Rhabdomyosarcoma, Breast Rhabdomyosarcoma, Anal Rhabdomyosarcoma, Cervical Rhabdomyosarcoma, Bile Duct Rhabdomyosarcoma, Gallbladder Rhabdomyosarcoma, Spindle Cell/Sclerosing Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma, Liver Rhabdomyosarcoma, Mediastinal Rhabdomyosarcoma, Ovarian Rhabdomyosarcoma, Prostate Rhabdomyosarcoma, and Orbit Rhabdomyosarcoma
OncoTree Name
Rhabdomyosarcoma
OncoTree Code
RMS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.